Common Ground: Like Gregory House before him, Justin Kirk's Dr. George Coleman is an acerbic misanthrope whose interpersonal flaws are outweighed by his brilliance in medicine.
The Twist: Aside from the obvious (Coleman treats animals, not humans), this series isn't a riff on Sherlock Holmes and is mostly playing for laughs. Coleman's boss is his ex-girlfriend (Joanna Garcia Swisher) and he's surrounded band a kooky veterinary staff that, unless you've been living under a rock, you already know includes an adorable monkey named Dr. Rizzo. (Don’t worry, Robert Sean Leonard; Wilson was cute too.)
Photo Credits: Jason Merritt/Getty Images; Sonja Flemming, CBS; Kevin Mazur, Getty Images for TNT; Michael Gladis; HBO; Gabe Ginsberg, WireImage; Frazer Harrison/Getty Images; Jenny Anderson/WireImage; Paul Archuleta, FilmMagic; Dan MacMedan, Getty Images