Common Ground: Like Gregory House before him, Justin Kirk's Dr. George Coleman is an acerbic misanthrope whose interpersonal flaws are outweighed by his brilliance in medicine.
The Twist: Aside from the obvious (Coleman treats animals, not humans), this series isn't a riff on Sherlock Holmes and is mostly playing for laughs. Coleman's boss is his ex-girlfriend (Joanna Garcia Swisher) and he's surrounded band a kooky veterinary staff that, unless you've been living under a rock, you already know includes an adorable monkey named Dr. Rizzo. (Don’t worry, Robert Sean Leonard; Wilson was cute too.)
Photo Credits: Matt Dinerstein/SHOWTIME; Jeff Kravitz/Getty Images; Ben Leuner / AMC; Alberto E. Rodriguez/Getty Images; Frederick M. Brown, Getty Images; Getty Images; Frederick M. Brown/Getty Images; Venturelli, WireImage; Ron Batzdorff/NBC; Paramount Network; Matt Dinerstein/Showtime