You Know Him From: He's fondly known for his role as Deputy Dewey in the Scream franchise, where he met now-estranged wife Courteney Cox.

You Know Her From: The Italian actress is George Clooney's ex. She appeared in multiple episodes of TNT's Leverage and briefly in Deuce Bigalow: European Gigolo.

You Know Her From: The reality star was Lauren Conrad's high school frenemy in MTV's Laguna Beach: The Real Orange County and later subbed in for LC as the star of The Hills in its final seasons.

You Know Him From: Offspring of Sonny and Cher, Chaz (formerly Chastity) went through a female-to-male gender transition, which was chronicled in an OWN documentary.

You Know Her From: She is the lead singer of Wilson Phillips and the wife of actor William Baldwin.

You Know Her From: She's a former district attorney-turned-HLN talk show host who vigorously covered the Casey Anthony case.

You Know Her From: She is an Olympic gold medal-winning goalie for the U.S. women’s soccer team, which heartbreakingly lost in the World Cup finals to Japan this year.

You Know Him From: Before playing Brot Monroe on ABC's daytime drama All My Children, he served as a U.S. Army infantryman in Iraq.

You Know Her From: She starred in John Waters' 1988 cult classic Hairspray before hosting her own successful talk show, Ricki Lake from 1993 to 2004.

You Know Him From: He's window dressing — aka the lone brother — on E!'s Keeping Up with the Kardashians.

You Know Him From: The NBA star plays for the Los Angeles Lakers and recently made headlines for wanting to change his name to Metta World Peace (and, yes, he’s the guy who was suspended for most of a season for an altercation with fans).