David (Bruce Willis) and Maddie (Cybill Shepherd), Moonlighting For decades, TV writers and producers have lived in fear of the Moonlighting curse after will-they-or-won't-they detective partners David and Maddie consummated their relationship midway through Season 3. The spark was lost and ratings quickly declined. Producers tried recapturing the magic at the end of Season 4 when Maddie impulsively married a man she hardly knew, but it was too little, too late, and the well-known behind-the-scenes tension between the show's stars didn't help matters.

George (T.R. Knight) and Izzie (Katherine Heigl), Grey's Anatomy George and Izzie are a prime example of what can go wrong when two friends try to take their relationship to the next level. It's too bad it took creator Shonda Rhimes a few episodes to figure out what viewers knew all along: These two had absolutely no chemistry together. Plus: Shame on George for cheating on Callie!

Although considered by some as one of the landmark TV couples of all time, others took issue with Sam and Diane's on-and-off relationship for many reasons. Some said they dominated too much of what was supposed to be an ensemble comedy. Even the producers themselves said they were "a little tired of their shenanigans" as the years wore on. Fortunately, the haters got their way when, after leaving Sam and Boston for good at the end of Season 5, Diane returned in the series finale years later to become engaged to Sam again and break up with him again because they realized they were never meant to be together.

We're not mad that the show tried to put House and Cuddy together. Or that it broke them up after a certain amount of time. These things happen in life. But ultimately, that pairing gave us two things we never wanted: 1) House, out of the blue, driving his car through Cuddy's living room and 2) a final season of the show without Cuddy. No amount of Vicodin will ever ease that pain.

Ultimately, Joey was just another roadblock the writers put between Ross and Rachel during the show’s 10-season run. Joey and Rachel's pairing was very polarizing, not only because Rachel belonged with Ross, but also because Joey pining for a woman was so out of character. Fortunately, the writers never let the pair make it to the bedroom, as their "uncomfortable" kissing helped them see they were better off as friends. We could've saved them the time if they'd just asked.

Luke (Scott Patterson) and Lorelai (Lauren Graham), Gilmore Girls After three seasons of trading barbs, their will-they-or-won't-they banter seemed as stale as a week-old cup of coffee. And yet somehow, the way the show put the grouchy town hermit and Stars Hollow's golden child together felt rushed. Viewers endured a nasty breakup, a long-lost teenage daughter plot, an engagement, and yet another breakup. And when the series finally came to a close, Luke and Lorelai fans only got a kiss with the promise of more, rather than the true happy ending these two deserved.

Having Booth and Brennan do the deed didn't outright ruin the show, but it just took so long for it to happen. By the time they finally consummated the relationship — and had a kid, no less! — we'd kind of moved on. And we didn't even get to see the magic moment that was six years in the making!

Xander (Nicholas Brendon) and Willow (Alyson Hannigan), Buffy the Vampire Slayer Where do we even start? Despite Willow's longstanding crush on Xander, the two always felt more like siblings than a romantic couple, so their illicit kiss just felt wrong on so many levels. (Yeah, yeah, they didn’t do it, but…) Not only were they cheating on their respective significant others at the time (poor Oz!), but this act also made the Scooby Gang weaker. A Slayer needs a steady support system!

Fran (Fran Drescher) and Mr. Sheffield (Charles Shaunessey), The Nanny The fish-out-of-water story loses steam when the fish begins to fit so well in its new surroundings. Such was the problem with Fran, who went from being the big-haired, brash and unconventional au pair to Mr. Sheffield's three children to being his adoring and completely boring (but still big-haired!) wife. Their relationship was a snooze-worthy and unrealistic portrait of a blissfully happy couple, and worse, she seemed to have far less time to watch after the kids once she married into the family. How does that work?

In an attempt to keep the show’s two main characters apart, Lex courted Lana, a high schooler six years his junior. Awkward! After seasons of using his extreme wealth to woo her, Lex eventually proposed to her in Season 6, with Lionel forcing her to walk down the aisle lest he kill Clark. Fortunately, Lex’s memories of their relationship were wiped out in the series finale. Thanks, Tess! Now can you do that to us too?

Fez (Wilmer Valderrama) and Jackie (Mila Kunis), That '70s Show After a few flirtatious kisses and a failed date, the foreign exchange student finally won over his princess and they become a couple during the last few episodes of the final season. Unfortunately, the two could never match the chemistry between Jackie's previous boyfriends Kelso and Hyde, and this pairing felt far too much like a last-ditch effort to wrap things up neatly.

Joey (Katie Holmes) and Dawson (James Van Der Beek), Dawson's Creek Of course the two main characters had to explore being together, but wouldn't a simple dating arc have sufficed? Once these best friends actually did the deed in the premiere episode of the final season, things just got awkward between them — especially since Dawson had a girlfriend at the time.

Despite the silly sitcom title, Angela is definitely Tony's boss, employing him as her housekeeper. And that's precisely why we hated that wretched last season with the two running around like teenagers who happen to also live in the same house. You should never date someone who's paying you. Plus: Dating someone living in the same house blurs the lines and creates unwarranted drama. Has reality TV taught us nothing?

OK, it was kind of sweet to see Kate bring out the softer side of hardened con man Sawyer, and their cage sex was pretty hot. But these two were never meant to be. Kate was always too wishy-washy in her feelings for Sawyer, and it was clear to everyone that her affections truly belonged to Jack. And Sawyer's sweet, time-trippy life with Juliet was pretty perfect too.

Carter and Abby's love story was one of ER's greatest. So when their romance came to an abrupt halt after Carter broke up with her in a letter from Africa, fans revolted, and his next girlfriend, Kem, got the brunt of it. Not only did fans find their relationship to be forced but complained that Kem was cold, critical and whiny — everything Abby wasn't.

Lois (Teri Hatcher) and Clark (Dean Cain), Lois and Clark: The New Adventures of Superman No spoiler alert needed: We knew these two were meant to be together. But the series waited only two years to squander the duo's love-hate relationship — and have Lois find out the truth about the real man behind Clark's glasses. Even worse, the producers seemed unsure about their decision as well. They gave Lois amnesia and Clark ended up with an imposter Lois right around the time of their wedding.

Of all the plot devices the writers used to keep Blair away from Chuck, this was by far the worst. Sure, B and Lonely Boy always shared a certain spark, but they worked best as frenemies from opposite worlds only forced together by Serena. After years of both making their distaste for the other well known, putting them together was like going against the natural order.