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A nonfraternization policy is issued to hospital staff in the wake of a complaint, leading the couples to worry about their relationships. Meanwhile, Emma and Owen discuss the future; and Richard asks the residents to research an atypical cancer case.
Arizona advises a patient who's facing a potential double amputation. Meanwhile, Derek doesn't fulfill a promise to Callie; a baby is abandoned outside of the hospital; and a doctor gets suspended for not adhering to the nonfraternization policy.
Meredith gets an assistant to help with her vein project. Meanwhile, Richard receives a special birthday gift from Bailey when she allows him to scrub in on an extraordinary case; Callie surprises Derek; and a young pregnant mom seeks help from Shane.