- Dropped out of college one credit short of graduating.
- First stand-up performance was in the back of a hamburger restaurant in New York City's Times Square.
- His big break was being booked on The Late Show With David Letterman in 2000 by guest host Janeane Garofalo.
- His 2002 talk show on Comedy Central, Late World With Zach, was canceled after nine weeks.
- Appeared in Fiona Apple's music video for "Not About Love."
- Has a Web show called "Between Two Ferns With Zach Galifianakis," which consists of offbeat interviews with celebrities.
- 2011, Emmy — Outstanding Guest Actor in a Comedy Series: Nominee
- 2013, Emmy — Outstanding Special Class - Short-Format Live-Action Entertainment Programs: Nominee
- 2014, Emmy — Outstanding Short-Format Live-Action Entertainment Program: Winner
- 2014, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Winner
- Quinn Lundberg — Wife
- Attended North Carolina State College, Raleigh, NC
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