- Lived in a Mendocino, CA, hippie commune as a child with seven other families.
- Parents are co-editors of the 1982 book Shaman Woman, Mainline Lady: Women's Writings on the Drug Experience.
- Says her hair is naturally blonde, but has been dyeing it brunette since the age of 12.
- Was signed to play Michael Corleone's daughter in 1990's The Godfather, Part III, but an illness forced her to give up the role. Director Francis Ford Coppola's daughter, Sofia, replaced her.
- Lampooned her 2001 shoplifting arrest when she hosted Saturday Night Live in May 2002.
- After a short break from acting, returned to big-budget films with her role as Spock's mother in 2009's Star Trek.
- Said that she could relate to her role as an aging ballerina in 2010's Black Swan since she's no longer cast as an ingenue.
- 2016, Critics' Choice Awards — Best Supporting Actress in a Movie Made for Television or Limited Series: Nominee
- 2010, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- 1991, Golden Globe — Best Performance by an Actress in a Supporting Role in a Motion Picture: Nominee
- 1994, Golden Globe — Best Performance by an Actress in a Supporting Role in a Motion Picture: Winner
- 1995, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- 2010, Screen Actors Guild Awards — Outstanding Performance by a Female Actor in a Television Movie or Miniseries: Nominee
- 1994, Oscar — Best Performance by an Actress in a Leading Role: Nominee
- 1993, Oscar — Best Performance by an Actress in a Supporting Role: Nominee
- 1994, BAFTA Film Awards — Best Actress in a Supporting Role: Nominee
- 1990, Independent Spirit Awards — Best Female Lead: Nominee
- Blake Sennett — Ex-significant Other
- Christian Slater — Ex-significant Other
- Cynthia Istas Horowitz — Mother
- David Pirner — Ex-significant Other
- Johnny Depp — Ex-fiancé
- Jubal Palmer — Half Brother
- Sunyata Palmer — Half Sister
- Uri Horowitz — Brother
- Matt Damon — Ex-significant Other
- Timothy Leary — Godparent
- Michael Horowitz — Father
- Birth Name: Winona Laura Horowitz
- Birth Place: Winona, MN
- Birthday: October 29, 1971, Scorpio
- Profession: Actor, Producer
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Grey's Anatomy is obviously a big influence on Tay Tay