- Started playing the ukulele when he was 8 years old.
- Played guitar in a cover band called the Knight Ryders during high school. He left the band for college and soon after, all but one of the remaining band members were killed in a car accident on their way home from a gig.
- Once performed stand-up under the name "Banjo Bill" Sadler.
- Won a Clarence Derwent Award and a Drama-Logue Award in 1985 for his portrayal of Sgt. Toomey in Neil Simon's Broadway hit Biloxi Blues, in which he starred opposite Matthew Broderick.
- Appeared as the Grim Reaper in 1991's Bill & Ted's Bogus Journey.
- Provided the voice of Victor in the video game Fallout: New Vegas.
- Jane Sadler — Mother
- William Sadler — Father
- Marni Joan Bakst — Wife
- Sadler Colley Bakst — Daughter
- State University of New York College at Geneseo, Geneseo, NY (BA in Drama, BS in Speech Communication, 1971); Cornell University, Ithaca, NY (MFA in Acting)
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