- As a kid, he performed in Chicago-area children's theaters and in school plays.
- Was senior class president in high school.
- Landed a Chevy commercial as a teen and then moved to Los Angeles where he worked as a telemarketer between acting assignments.
- TV acting debut was on China Beach in 1989.
- Broke into films in 1993 with an appearance in Rudy.
- Met Jon Favreau on the Rudy set and the two forged a close bond; Favreau wrote Swingers and suggested him for the role of fast-talking ladies man Trent Walker.
- In the late 1990s starred in Steven Spielberg's The Lost World: Jurassic Park and in the Gus Van Sant remake of Psycho.
- Skydived over Chicago in 2010 as part of the city's annual Air and Water Show.
- 2007, People's Choice Awards — Favorite Leading Man: Winner
- 2007, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- 2006, People's Choice Awards — Favorite On Screen Match Up: Winner
- Valerie Vaughn — Sister
- Vernon Lindsay Vaughn — Son
- Kyla Weber — Wife
- Locklyn Kyla Vaughn — Daughter
- Vernon Vaughn — Father
- Shea Vaughn — Mother
- Victoria Vaughn — Sister
- Jennifer Aniston — Ex-significant Other
- Birth Name: Vincent Anthony Vaughn
- Birth Place: Minneapolis, Minnesota, United States
- Profession: Actor, Producer
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