- Worked as a waiter in the Transit Authority dining room on the 44th floor of the World Trade Center for three years.
- Starred in regional theater before breaking into movies.
- Gained 40 pounds to play John Gotti in Witness to the Mob (1998).
- Provided the voice of Sonny Forelli in the video game Grand Theft Auto.
- Has freely admitted his past addiction to drugs and credits friend and Heat costar Robert De Niro with getting him into rehab.
- Appeared on the shows Celebrity Rehab With Dr. Drew and Sober House With Dr. Drew in 2010; credits Dr. Drew Pinsky and drug counselor Bob Forrest with saving his life.
- Hobbies include playing intramural football, drawing and reading.
- 2000, Golden Globe — Best Performance by an Actor in a Miniseries or Motion Picture Made for Television: Nominee
- 1998, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- Paul Sizemore — Brother
- Janelle McIntire — Ex-significant Other
- Thomas Sizemore — Father
- Jagger Sizemore — Son
- Judith Sizemore — Mother
- Heidi Fleiss — Ex-significant Other
- Maeve Quinlan — Ex-wife
- Jayden Sizemore — Son
- Attended Michigan State University, East Lansing, MI; Wayne State university, Detroit, MI (BFA in Theater); Temple University, Philadelphia, PA (MFA in Theater, 1986)
- Birth Name: Thomas Edward Sizemore Jr.
- Birth Place: Detroit, MI
- Profession: Actor
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