- Was inspired to be an actor as a kid after watching Laurel and Hardy movies.
- Was a member of Chicago's Remains Theatre, founded by William Petersen and Gary Cole.
- Breakout role was playing serial killer Buffalo Bill in The Silence of the Lambs.
- Was uncredited in the J.J. Abrams-penned Joy Ride (2001); he provided the voice-overs for the murderous truck driver Rusty Nail.
- Successfully segued from film to TV when cast as Captain Leland Stottlemeyer on Monk, a role he played from 2002 to 2009.
- 2007, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- Kim Phillips — Wife
- Melissa Levine — Daughter
- Mac Levine — Son
- Marlboro College, Marlboro, VT (1979); University of Chicago, Chicago, IL (MFA)
- Birth Name: Frank Theodore Levine
- Birth Place: Bellaire, OH
- Profession: Actor
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