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A thief is shot and killed after robbing a family and beating them, which makes the Reagans ponder how far they would go to protect their loved ones. Meanwhile, Frank struggles with charges brought against a girl arrested at a rally due to her identity.
The second season concludes with Frank attempting to stop a biological-weapons attack on the city, while trying to keep it a secret from his family on Mother's Day. Meanwhile, a long-standing conflict between Danny and Jamie comes to a head.