- Named after her aunt Karen Grammer, who was murdered in 1975.
- First acting role was an uncredited appearance on Cheers.
- Appeared as a dancer in MTV's Learn to Hip Hop: Volume 2 (2003).
- In 2006, became the third actress to portray Dr. Lucy Montgomery on As the World Turns.
- Best known for her role as popular sorority girl Casey Cartwright on the ABC Family series Greek.
- Jude Grammer — Half Brother
- James Hesketh — Husband
- Emmett Emmanual Hesketh — Son
- Doreen Alderman — Mother
- Kayte Walsh — Stepmother
- Greer Grammer — Half Sister
- Faith Grammer — Half Sister
- Gabriel Grammer — Half Brother
- Kelsey Grammer — Father
- Mason Grammer — Half Sister
- Attended Marymount Manhattan College, New York, New York, United States
Season 2, Episode 1
- Birth Name: Spencer Karen Grammer
- Birth Place: Los Angeles, California, United States
- Birthday: October 9, 1983, Libra
- Profession: Actor
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