Rob Moore

Directed by filmmaker Jesse Dylan (Will.i.am's iconic 'Yes We Can' video), the spot stars Ren e Zellweger, Rob Lowe, Josh Groban, Derek Fisher, Michael Strahan, Minka Kelly, and Mandy Moore among many others, conveying the core message: it's 'Up 2' each of us to play a role in ending cancer.

The fight against cancer isnt just Up2 someone else. As this new SU2C PSA, directed by Jesse Dylan and featuring Renee Zellweger Rob Lowe, Billy Bob Thornton, Michael Strahan, Minka Kelly, Mandy Moore and other stars demonstrates, its Up2 all of us.

Seven friends, recent college graduates, are searching for a place in the real world, as they face issues of career and commitment. Leslie and Alec (Ally Sheedy and Judd Nelson) try to save a crumbling romance. Wendy (Mare Winningham), a shy virgin, hides a love for Billy (Rob Lowe), a reluctant father/husband still searching for goals. Kevin (Andrew McCarthy) is a cynical writer who scorns love until he realizes he's in love with his best friend's girl. Kirbo (Emilio Estevez), a law student, obsessively pursues an older woman. The beautiful, neurotic Jules (Demi Moore) paints a poignant picture of life in the fast lane. Against the backdrop of St. Elmo's, their local hang-out, they save, betray and love one another as only the closest of friends can.

The fight against cancer isnt just Up2 someone else. As this new SU2C PSA, directed by Jesse Dylan and featuring Renee Zellweger Rob Lowe, Billy Bob Thornton, Michael Strahan, Minka Kelly, Mandy Moore and other stars demonstrates, its Up2 all of us.