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Townspeople brace for the worst when a new girl arrives---with symptoms of smallpox. Betty: Carol Leigh. Coyle: Ed Ames. Lucas: Chuck Connors. Mark: Johnny Crawford. Lou: Patricia Blair. Doc: Ralph Moody. Molly: Maurine Dawson. Micah: Paul Fix.
Ben competes with his old rival Barney Fuller to win the railroad's lumber contract. Ben: Lorne Greene. Adam: Pernell Roberts. Hoss: Dan Blocker. Joe: Michael Landon. Martha: Melora Conway. Gabe: Ralph Moody. Watts: Raymond Guth.