- As a teen, formed a tap-dancing troupe which won Ted Mack's Amateur Hour and appeared on The Jackie Gleason Show.
- First screen appearance was in the 1968 biker flick The Savage Seven; also in '68 appeared with James Garner and Debbie Reynolds in How Sweet It Is! which was scripted by her brother, Garry Marshall.
- Appeared with an unknown Farrah Fawcett in a 1970s Head & Shoulders TV commercial.
- Big break came when brother Garry cast her as a secretary on his sitcom The Odd Couple and later in two of his other ABC series: Happy Days and Laverne & Shirley.
- Was given the directorial reins on Whoopi Goldberg's 1986 movie Jumpin' Jack Flash, even though her directing experience was limited to a few TV episodes.
- Became the first woman to direct a $100 million-grossing film with Big; other directorial efforts include the Oscar-nominated Awakenings and A League of Their Own.
- Is an avid collector of sports memorabilia.
- 1980, Golden Globe — Best Performance by an Actress in a Television Series - Musical or Comedy: Nominee
- 1979, Golden Globe — Best Performance by an Actress in a Television Series - Musical or Comedy: Nominee
- 1978, Golden Globe — Best Performance by an Actress in a Television Series - Musical or Comedy: Nominee
- Michael Henry — Ex-husband
- Rob Reiner — Ex-husband
- Garry Marshall — Brother
- Tracy Reiner — Daughter
- Marjorie Ward Marshall — Mother
- Tony Marshall — Father
- Ronny Hallin — Sister
- Attended University of New Mexico, Albuquerque, NM