Jared Padalecki and Jensen Ackles
"Sorry, Sam, you are well and truly alone."
That taunt at the end of last year's Supernatural finale sets up the psychological drama for Season 8, which kicks off Wednesday (9/8c, The CW). Sam and Dean Winchester (Jared Padalecki and Jensen Ackles) reunite in the premiere, but all is not as it once was. It's been a year since they've fought evil together, and each of the brothers have spent that time in very different, life-altering ways.