- Parents immigrated to Britain from Iran in 1957.
- Earned degrees in English and theater studies in college.
- After college, was rejected by 16 drama schools.
- Acted in experimental theater in the Czech Republic before turning to stand-up comedy; a one-man show (written by his wife, playwright Annabel Knight) won an award at the 1994 Edinburgh (Scotland) Fringe Festival.
- Was chosen "Best Comic of 1996" on The Big, Big Talent Show on Britain's ITV network.
- In the U.S., was a regular on the 2002 ABC fantasy Dinotopia and Whoopi Goldberg's 2003-04 NBC sitcom, Whoopi.
- Won a Persian Golden Lioness Award in 2006.
- His 2007-09 BBC sketch show, The Omid Djalili Show, was Britain's first ever hosted by an Anglo-Iranian.
- Played Picasso in the 2004 biopic Modigliani; other film credits include Notting Hill, The Mummy, The World Is Not Enough, Gladiator, Casanova, Pirates of the Caribbean: At World's End and Sex and the City 2.
- Louis Djalili — Son
- Ahmad Djalili — Father
- Isabella Djalili — Daughter
- Danny Djalili — Son
- Annabel Knight — Wife
- University of Ulster, Coleraine, Northern Ireland (1988)