Inspired by Daws Butler, the voice of Huckleberry Hound, Yogi Bear and various other Hanna-Barbera characters, and received private lessons from him.
While most famous as the voices of The Simpsons' Bart and Rugrats' Chuckie, has performed lead voices on many cartoon series (including Shirt Tales, Pound Puppies, Kim Possible, Goof Troop and Bonkers), since getting her start as the voice of Richie Rich's girlfriend Gloria in 1980.
An ad-lib---"Eat my shorts!"--- became one of Bart Simpson's most famous catchphrases.
Created The Kellys, an animated series about a family of stock-car racers, coproduced by her Internet animation and production company, SportsBlast.
In addition to being a member of many children's charities, is cofounder of Happy House, a charity devoted to building better families.
Gave the 2012 commencement address at Ohio University.