- Before she became a stand-up comic, her jobs included monitor for a phone sex line.
- Owned a comedy club in Baltimore, MD, in 1994 called Mo'Nique's.
- Cohosted a morning radio show in Baltimore in the early 1990s.
- First TV role was on the series The Parkers, debuting in 1999. She would go on to win four NAACP Image Awards as Outstanding Actress in a Comedy Series.
- Became the first woman, in 2002, to host the syndicated show Showtime at the Apollo.
- Published her first book, Skinny Women Are Evil: Notes of a Big Girl in a Small-Minded World, in 2003.
- Created and starred in Mo'Nique's Fat Chance, the first reality-TV beauty pageant for full-figured women.
- The Mo'Nique Show, a late-night talk show, premiered on BET in 2009.
- 2009, Sundance Film Festival — Special Jury Prize for Acting (Dramatic): Winner
- 2010, Golden Globe — Best Performance by an Actress in a Supporting Role in a Motion Picture: Winner
- 2009, Screen Actors Guild Awards — Outstanding Performance by a Female Actor in a Supporting Role: Winner
- 2009, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- 2009, Oscar — Best Performance by an Actress in a Supporting Role: Winner
- 2009, BAFTA Film Awards — Best Supporting Actress: Winner
- Steven Imes — Brother
- Shalon Watkins Sr. — Ex-husband
- Alice Imes — Mother
- Millicent Imes — Sister
- Sidney Hicks — Husband
- Mark Jackson Jr. — Son
- Mark Jackson Sr. — Ex-husband
- Steven Imes Jr. — Father
- Shalon Watkins Jr. — Son
- David Hicks — Son
- Marvin Dawson — Ex-fiancé
- Jonathan Hicks — Son
- Gerald Imes — Brother
- Attended Morgan State University, Baltimore, MD
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