- The son of a defense contractor, he lived in California and Texas before attending high school in Turkey.
- Briefly followed in his father's footsteps and worked as a defense contractor himself in Iran in the late 1970s.
- Worked as a cab driver, bookkeeper and janitor while honing his craft in local theater.
- Met his second wife, Arlene, on the set of The X-Files; she was Gillian Anderson's stand-in. (She was later cast as Skinner's secretary.)
- Returned to the series Supernatural in 2010 in the recurring role of Sam and Dean's grandfather, a part he originally played in a 2008 guest spot on the show.
- 1997, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- 1996, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- 1998, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- Debbie Andrews — Ex-wife
- Vito Pileggi — Father
- Maxine Pileggi — Mother
- Nick Pileggi — Brother
- Arlene Warren — Wife
- Sawyer Pileggi — Daughter
- University of Texas, Austin, TX; attended Fullerton College, Fullerton, CA; attended University of Maryland, Munich, Germany
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- Birth Place: Portland, OR
- Profession: Actor
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