Launched modeling career at age 11, when photographer Richard Avedon chose her as one of Revlon's Most Unforgettable Women in the World; first cover was for the October 1987 edition of the Italian magazine Lei.
Attended high school with Christina Applegate and then appeared with her in an episode of Married...With Children titled "Fair Exchange."
Created two different videos for her 1994 hit "Gentlemen Who Fell" from her album The Divine Comedy; the first one was directed by Lisa Bonet and featured actor Harry Dean Stanton, but she was dissatisfied with the end result and shot a new one in black and white.
Performed all of her own stunts in the 2002 sci-fi horror flick Resident Evil.
Cofounded clothing line Jovovich-Hawk (2003-08) with model Carmen Hawk. The successful line included a 2008 collection for Target's GO International campaign. Pieces from the duo's 2008 Target collaboration were included in Target's 2011 limited-edition designer collective.