Six months after adventurer Dr. Emmet Cole goes missing in the Amazon, his location beacon sends out a signal; Emmet's wife, Tess, along with her son and Emmet's film crew, embark on a journey to find him.
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Off-track betting gambler Anica (guest star Cynthia Nixon) collapses in front of House while they're both following horse races at the site. Confused by her symptoms and what he witnessed after she collapsed, he instructs medics to take her to Princeton Plainsboro and takes her case. After the team discovers she's been seeing a number of doctors for a variety of supposed illnesses, everyone but House thinks it's Munchausen's, a disease that causes people to fake symptoms for the medical attention. House butts heads over Anica's medical care with his former team member and current supervisor Dr. Foreman. Standing by the Munchausen's diagnosis, Foreman sends Anica home over House's objections. Convinced she is legitimately ill, House draws a confession out of Anica that may save her life.
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