- Was born on Easter.
- Acting career started at the age of 4 when she did a commercial for a bathtub toy.
- Has a lazy eyelid that causes her right eye not to open as wide as the left.
- Helped found Hartbreak Films, a production company she runs with her mother and stepfather.
- Narrated 1994's Peter and the Wolf, a classical album for children.
- Siblings Elizabeth, Emily and Brian appeared in Melissa's TV series, Sabrina, the Teenage Witch.
- Has a tattoo of a cross on the back of her neck.
- Opened a candy shop in Sherman Oaks, CA, called Sweetharts in 2009.
- Made a pact with her husband to move out of Los Angeles before their second child went to kindergarten; the pair eventually settled down in Westport, CT, in 2009.
- Became interested in rowing in 2010 when she joined a rowing club near her home in Connecticut.
- Alexandra Hart-Gilliams — Half Sister
- Billy Hart — Father
- Brian Hart — Brother
- Emily Hart — Sister
- Tucker Wilkerson — Son
- Trisha Hart — Sister
- Leslie Gilliams — Stepfather
- Mark Wilkerson — Husband
- Mason Walter Wilkerson — Son
- Elizabeth Hart — Sister
- Mackenzie Hart — Half Brother
- Paula Hart — Mother
- Samantha Hart-Gilliams — Half Sister
- Braydon Hart Wilkerson — Son
- Attended New York University, New York, NY
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- Birth Place: Smithtown, NY
- Birthday: April 18, 1976, Aries
- Profession: Actor, Producer, Director