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This is an anime-original episode. In a small town in Colorado, Sam and Dean investigate a series of cattle mutilations, the beasts have been drained of their blood. They run across Jason, a hunter who specializes in vampires, but wonder why he’s in town. Dean takes a shine to a whimpy kid, Ryan. But the kid and his father are hiding something. It’s revealed Jason is in town to kill them. They’re both vampires who have sworn off killing humans. Can Sam and Dean save two monsters that they are trained to hunt and gank?!

Watch a sneak peek of the Nikita season premiere.

The Chuck cast and producers discuss the hit show at the 2008 Comic-Con in San Diego.

This is a remake of the live-action Season 2 episode #16 "ROAD KILL". Sam and Dean investigate a series of strange accidents on a mountain road. They come across Molly who insists she and her husband just crashed their car, problem is her husband and the car are missing!! Dean and Sam keep Molly close as they find and burn the bones of the suspected ghost causing the accidents. But not everything is as it seems... including Molly.

While driving down a deserted road, Sam and Dean are startled when a bloody woman, Molly, bolts in front of the Impala, screaming for help from the crazy farmer who is chasing her.

It's time for another Chrismukkah in Orange County. Also available on iTunes

When Summer tries to become the gossip-loving girl she once was, she realizes that Brown may have changed her forever. Also available on iTunes

Ryan travels to Mexico--with a stubborn Seth in tow--to put an end to his turmoil in the only way he knows how, but he comes up empty in quest for revenge. Also available on iTunes

In the fourth season premiere, everyone struggles to adjust to life without Marissa. Also available on iTunes

Chance reunites with a fiery former flame when he is called to South America to rescue an archeologist whose discovery of a lost treasure makes him the target of a deadly bounty hunter - and a South American army. Guest stars include KRIS MARSHALL (My Family, Murder City) as Doug, KIM COATES (Sons of Anarchy, Prison Break, CSI: Miami) as Bertram and LEONOR VARELA (Cleopatra, Where God Left His Shoes, Innocent Voices) as Maria.

The Ring is closing in on Chuck and Operation Bartowski. Fortunately, Chuck's dad, Stephen (recurring guest star SCOTT BAKULA), is working hard to save his son. Meanwhile, Casey must secretly protect his daughter from the Ring, and Big Mike receives some serious news about the Buy More.

Craig Silverstein catches us up: Amanda's in control, Percy goes rogue, and Michael cuts his hair. Catch Nikita Fridays at 8/7c on The CW.