Grew up on a Wyoming cattle ranch and attended early grades in a one-room schoolhouse where his mother was the teacher.
Intended to work on Wall Street after graduating from Columbia University but instead took a modeling job, which led to acting in commercials.
Made television series debut guest-starring on the 1992 episode of Wings titled "Say It Ain't So, Joe" as the pitcher who broke the high-school pitching record set by Joe (Tim Daly).
Big break came in 1994 playing eldest brother Charlie Salinger in the drama Party of Five.
Was voted one of the 50 Most Beautiful People in the World by People magazine in 1996.
Auditioned for the role of Sawyer on Lost until producers decided to rewrite a minor part and cast him in the lead role as Dr. Jack Shepherd.
A fan of cartoons and comic books, he eagerly accepted the role of Racer X in the 2008 film version of Speed Racer.
2006, Golden Globe — Best Performance by an Actor in a Television Series - Drama: Nominee
2010, Emmy — Outstanding Lead Actor in a Drama Series: Nominee
2005, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Winner
Bayard Fox — Brother
Loretta Fox — Mother
Kyle Allison Fox — Daughter
Francis Fox Jr. — Brother
Margherita Ronchi — Wife
Byron Fox — Son
Francis Fox — Father
Columbia University, New York, New York, United States (BA in Economics, 1989); attended Atlantic Theater Company, New York, New York, United States; attended School for Film and Television, New York, New York, United States
Birth Name: Matthew Chandler Fox
Birth Place: Abington, Pennsylvania, United States