- Is of Irish, Czech and Polish origin; surname, of Czech origin, is pronounced "rice-kub."
- Moved to San Francisco at 21 to attend art school. In the Bay area, she became a performance artist and then a stand-up comic.
- Was an original cast member of Mr. Show With Bob and David in 1995; left the series when she broke up with creator David Cross.
- Replaced friend Janeane Garofalo on The Larry Sanders Show.
- Is one half of Girls Guitar Club (with Karen Kilgariff), a comedy act.
- Has appeared in two Paul Thomas Anderson-directed movies: Magnolia and Punch-Drunk Love; other notable film appearances include Sweet Home Alabama, Legally Blonde 2, and Julie & Julia.
- Biggest break came in 2003 when she was cast as tech-savvy Chloe O'Brian on 24.
- Appeared as Lynette "Squeaky" Fromme in the 2004 TV-movie Helter Skelter.
- Appears in the self-penned, one-woman theatrical show Mary Lynn Spreads Her Legs.
- Is a prolific painter.
- 2004, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- 2006, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- Tony Rajskub — Father
- Valentine Anthony Rolph — Son
- Matthew Rolph — Husband
- David Cross — Ex-significant Other
- Jon Brion — Ex-significant Other
- Betty Rajskub — Mother
- Attended Detroit College for Creative Studies, Detroit, MI; attended San Francisco Art Institute, San Francisco, CA
- Birth Place: Detroit, MI
- Birthday: June 22, 1971, Cancer
- Profession: Actor, Comedian
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