- While attending the University of Illinois, she trained as an opera singer and sang at the Nashville theme park Opryland.
- Landed an understudy role in a stage production of West Side Story after moving to New York in the early 1980s.
- Continued her stage work as she turned in a critically acclaimed performance as Viola in Shakespeare's Twelfth Night.
- First film role was in Scarface (1983) as Al Pacino's sultry sister, Gina Montana.
- Moved to London in the early 1990s with her film director husband, Pat O'Connor.
- Before replacing Eric Bogosian in the lead role on NBC's Law & Order: Criminal Intent, she had a recurring role on the CBS drama Without a Trace.
- 1986, Oscar — Best Performance by an Actress in a Supporting Role: Nominee
- 1987, Golden Globe — Best Performance by an Actress in a Supporting Role in a Motion Picture: Nominee
- 2003, Tony — Actress (Musical): Nominee
- Pat O'Connor — Husband
- Mary Mastrantonio — Mother
- Jack O'Connor — Son
- Frank Mastrantonio — Father
- Declan O'Connor — Son
- Attended University of Illinois, Champaign, IL
Season 8, Episode 1
- Birth Place: Oak Park, IL
- Birthday: November 17, 1958, Scorpio
- Profession: Actor, Singer
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