- Worked as a copy editor for Popular Mechanics as well as an assistant at Rolling Stone magazine after leaving graduate school.
- Held positions of fact checker and the First Chief of Research for Spy magazine; also wrote about music for Hit Parader magazine.
- Launched her stand-up career in the early '90s, working various clubs in New York City and Los Angeles, where she developed a following for her raunchy and caustic routines.
- Breakthrough came in 2002, when she was the only female comedian invited to skewer Chevy Chase at the New York Friar's Club Roast on Comedy Central.
- Frequent guest of The Howard Stern Show.
- Landed first cable stand-up special, The Queen of Mean, in 2002.
- Put out first DVD, Take It Like a Man, in 2005; followed it up with Dirty Girl in early 2007.
- Nancy Lessard — Sister
- Jimmy Cannizzaro — Husband (separated)
- Syracuse University, Syracuse, New York, United States (BA in Journalism, 1983); Harvard University, Radcliffe Institute for Advanced Study, Cambridge, Massachusetts, United States (1986); attended Columbia University, New York, New York, United States
- Birth Name: Lisa Lampugnale
- Birth Place: Trumbull, Connecticut, United States
- Profession: Comedian, Actor
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