Sam and Dean run into a small town where the citizens know how to fight demons and a "prophet" has a close personal connection with angels. Or does she? After Cas and Dean's faith takes a vacation, they vent their frustrations out in very different ways. And by the end of the hour, Dean follows his heart in a very surprising way.
"99 Problems" starts out with Dean and Sam being chased in the Impala which is just an awesome way to start out any episode. Sam and Dean seem slightly injured. The car is forced to stop and when the brothers try to get away, demons grab them. The brothers are fortunately saved by some people wielding a fire hose full of holy water. This rescue takes Sam and Dean by complete surprise. They're used to having to explain demons to people, but this time around they're having the villainous supernatural beings explained to them. These townsfolk take Sam and Dean back to their church where everybody's got a gun. Even the preacher is in on the hunting business. Sam and Dean learn their reputation precedes them when a young woman tells them she talks to angels. She knows almost everything about the siblings. Dean guesses she's a prophet.