A new intern has an impact on Brennan.
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When Dr. Sebastian Charles (guest star Ron Livingston, "Little Black Book," "Sex and the City"), renowned physician and head of an international organization to fight the spread of tuberculosis among the poor in Africa, is rushed to Princeton Plainsboro Teaching Hospital after collapsing, he immediately determines all the symptoms are from TB. Dr. House has a different opinion and requests additional tests to help determine the cause of his illness. The case begins to get media attention and Dr. Charles sees his chance to further his cause by refusing to submit to any additional tests and take necessary medication in order to gain media exposure for the inadequacies of the medical system for the poor in Africa. As House confronts his patient on live television, his medical condition deteriorates and the team takes over to try to save his life. Meanwhile, Foreman fills in for House in the clinic with disastrous results and Cameron sees eye to eye with Dr. Charles and his cause.
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On Valentine's Day, an Iranian fighter jet accidentally shoots down a British passenger plane--killing 100 people--but C.J. is reluctant to awaken the President even as the hawkish British prime minister considers bombing Iran's nuclear reactors in retaliation. After learning that the passenger jet was mistaken for a U.S. spy plane, Bartlet consults with British ambassador Lord John Marbury (recurring guest star Roger Rees - "Cheers"), and they debate whether a strike is the perfect excuse to destroy the atomic sites or if it would set back reform movements in Iran. Meanwhile, Abbey and C.J. feud over the President's schedule for total rest; Toby and a legal professor try to write a new democratic constitution with representatives of Belarus; and everyone keeps dodging the traditional White House appointment with Miss Universe. Christopher Lloyd ("Taxi," the "Back to the Future" films) guest stars as law professor Lawrence Lessig.
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Phoebe believes that the cat that jumped into her guitar case in Central Perk contains the spirit of her adoptive mom.
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The Bike Patrol investigates a series of home invasion robberies and bring in a psychic to help them. Cory discovers that her idolized older brother might be a "dirty" cop.
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