- Studied engineering in college.
- Began his entertainment career performing stand-up comedy in New York and Los Angeles.
- Coproduced and cowrote Eddie Murphy's hit concert film Raw (1987).
- Hosted a short-lived late-night talk show, The Keenen Ivory Wayans Show (1997-98).
- Appeared in the documentary The Black List: Volume One (2008), which consisted of interviews with influential black Americans.
- Is a vegetarian, and has appeared in a "Do It for Someone You Love" PSA as part of a campaign to encourage people to eat healthier.
- Says he prefers directing small-budget films.
- Received the Entertainment Icon Award at the 15th Annual American Black Film Festival in July 2011.
- 1992, Emmy — Outstanding Variety, Music or Comedy Program (series): Nominee
- 1991, Emmy — Outstanding Variety, Music or Comedy Program: Nominee
- 1991, Emmy — Outstanding Individual Performance in a Variety or Music Program: Nominee
- 1991, Emmy — Outstanding Writing in a Variety or Music Program: Nominee
- 1990, Emmy — Outstanding Writing in a Variety or Music Program: Nominee
- 1990, Emmy — Outstanding Variety, Music or Comedy Series: Winner
- 1992, Emmy — Outstanding Individual Achievement in Writing in a Variety or Music Program: Nominee
- Brittany Daniel — Ex-significant Other
- Daphne Ivory Wayans — Daughter
- Damon Wayans — Brother
- Diedre Wayans — Sister
- Elvira Wayans — Mother
- Vonnie Wayans — Sister
- Elvira Wayans — Sister
- Marlon Wayans — Brother
- Nadia Wayans — Sister
- Shawn Wayans — Brother
- Howell Wayans — Father
- Keenen Ivory Wayans Jr. — Son
- Nala Wayans — Daughter
- Daphne Polk — Ex-wife
- Dwayne Wayans — Brother
- Kim Wayans — Sister
- Bella Wayans — Daughter
- Jolie Ivory Imani Wayans — Daughter
- Attended Tuskegee University, Tuskegee, Alabama, United States
- Birth Place: New York, New York, United States
- Birthday: June 8, 1958, Gemini
- Profession: Actor, Producer, Director, Screenwriter, Comedian
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Grey's Anatomy is obviously a big influence on Tay Tay