Katie Jacobs

Get a taste of what to expect in Season 8 of House with this special bonus clip from the premiere.

From the House episode "Bombshells" directed by Greg Yaitanes, Written by Liz Friedman & Sara Hess. "Get Happy" Written by Harold Arlen and Ted Koehler, Choreographed by Mia Michaels, Arranged by Jon Ehrlich, Music Produced by Jon Ehrlich and Jason Derlatka, Mixed by Steve Kaplan.

House and the team take on the case of a woman, Julia (guest star Callies), who is in an open marriage and becomes ill during a date with her on-the-side boyfriend. As perplexing as the case is, Julia'?s happy and healthy, yet polygamous relationship is equally baffling to the team. Meanwhile, House tests Wilson?s relationship with Sam (guest star Cynthia Watros).

Treating a drug addict patient results in House examining his life, his future and his own personal demons.

Dr. Gregory House is devoid of bedside manner and wouldn't even talk to his patients if he could get away with it. Dealing with his own constant physical pain, he uses a cane that seems to punctuate his acerbic, brutally honest demeanor. House's roster of medical cases are the inexplicable ones other doctors can't solve, and he has assembled an elite team of young medical experts to help him in his effort to solve these diagnostic mysteries.

In the Season Six finale, House, driven by the loss of a patient and confronted with the unexpected news of Cuddy's engagement, spiraled into despair and considered treating his anguish with Vicodin. In a surprising turn, Cuddy called off her engagement and admitted to House she loves him. Also, Thirteen submitted her leave of absence from the hospital, prompting questions about the status of her health. As Season Seven begins, House and Cuddy attempt to make a real relationship work and face the question as to whether their new relationship will affect their ability to diagnose patients.

Beginning with a premiere set almost entirely inside the psychiatric hospital, Season Six will explore House's long and twisted road to recovery: Can he find some version of sanity and normalcy? Can he stay away from the workplace that arguably drove him to mental instability but is also the only stable foundation in his life? Can Princeton-Plainsboro continue its celebrated Department of Diagnostics without him? How will Cuddy's relationship with House change, now that their imagined affair is out in the open?

In the Season Three finale, the set-in-his-ways House was confronted with a series of major changes to his team - neurologist Dr. Eric Foreman (Omar Epps) left Princeton Plainsboro because he didn't want to turn into House; House randomly fired old-money intensivist Dr. Robert Chase (Jesse Spencer); and immunologist Dr. Allison Cameron (Jennifer Morrison) resigned, knowing House will be completely unaffected by her decision. But any effects of this "house-cleaning" on House, or the changes it may bring professionally or personally, remain to be seen...

House will do whatever it takes to solve a case before it's too late, including sending a member of his team to break into a patient's home in search of clues, to attempting a controversial, trial-and-error form of treatment to see how a patient responds. House's methods may be suspect, but his results are not - he saves lives no one else can.

In the Season Four finale, a massive bus accident left House without recollection of four hours prior to the accident. The team helped House discover Wilson's girlfriend Amber was on the bus with him and was fatally injured. Wilson had to face the shocking realization that House was directly involved in Amber's death. As Season Five opens, with his friendship with Wilson shattered, House must determine if he's responsible for Amber's death and Wilson must decide if House is a destructive force in his life, while Cuddy attempts to advance a reconciliation between the two.

In the season 2 finale, House suffered multiple gunshot wounds inflicted by a former patient's husband determined to carry out retribution for House's treatment of his wife's case. In a shocking surprise to his co-workers, House comes through the ordeal with a slightly new perspective on his treatment of patients - but will it affect how he makes medical decisions? And will it last?

Get a taste of what to expect in Season 8 of House with this special bonus clip from the premiere.