- Expelled from school for setting a science lab on fire.
- Discovered at 16 by a casting agent who met him in a pool hall in Cork, Ireland.
- First acting job was in a soup commercial.
- Favorite actors are Peter O'Toole, Richard Harris and Richard Burton.
- Became a celebrity ambassador for the Hope Foundation in 2008.
- Struggles with alcohol abuse and has been in and out of rehab since 2005.
- 2005, Emmy — Outstanding Lead Actor in a Miniseries or a Movie: Nominee
- 2006, Golden Globe — Best Performance by an Actor in a Miniseries or Motion Picture Made for Television: Winner
- 2009, Golden Globe — Best Performance by an Actor in a Television Series - Drama: Nominee
- 2008, Golden Globe — Best Performance by an Actor in a Television Series - Drama: Nominee
- Alan O'Keeffe — Brother
- Jamie O'Keeffe — Brother
- Geraldine Myers — Mother
- John O'Keeffe — Father
- Paul O'Keeffe — Brother
- Reena Hammer — Ex-significant Other
- Mara Lane — Significant Other
- Birth Name: Jonathan Michael Francis O'Keefe
- Birth Place: Dublin, Ireland
- Birthday: July 27, 1977, Leo
- Profession: Actor
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Grey's Anatomy is obviously a big influence on Tay Tay