- Worked with actress Frances Sternhagen in 1981's sci-fi flick Outland; she was later cast as his character's mother on Cheers.
- His speaking part in Richard Attenborough's 1982 drama Gandhi was dubbed by Martin Sheen.
- Was the only Cheers cast member to have lived in Boston, where the show was set.
- Appeared as his Cheers alter ego on five other TV series along with costar George Wendt: The Tortellis, St. Elsewhere, Frasier, Wings and The Simpsons.
- Began a long and lucrative relationship with Pixar Animation Studios in 1995 as the voice of the perpetually inquisitive piggy bank named Hamm in the Toy Story movies.
- Helped create the organization ChildrenWithDiabetes.com, of which he is the chairman.
- Holds a red belt in karate.
- Stepped in as Vincent Pastore's replacement on the fourth season of Dancing With the Stars, partnering with pro Edyta Sliwinska.
- Is a senior fellow with Center for America, which focuses on social justice, with an emphasis on employment. He is a founder of Nuts, Bolts & Thingamajigs, which also pushes for job opportunities.
- During a 2012 interview, he supported the idea of privatizing the postal system; no telling how his Cliff Clavin postman character from Cheers might have taken that!
- 1985, Emmy — Outstanding Supporting Actor in a Comedy Series: Nominee
- 1986, Emmy — Outstanding Supporting Actor in a Comedy Series: Nominee
- Elizabeth Georgia Stiny — Ex-wife
- James John Ratzenberger — Son
- Nina Katherine Ratzenberger — Daughter
- Deszo Alexander Ratzenberger — Father
- Catarina Toumei — Ex-fiancée
- Bertha Grohowski Ratzenberger — Mother
- Lindsay McGrail — Ex-fiancée
- Sacred Heart University, Bridgeport, CT (BA in English, 1971; Doctorate in 1992)
Season 3, Episode 20
- Birth Name: John Deszo Ratzenberger
- Birth Place: Bridgeport, CT
- Birthday: April 6, 1947, Aries
- Profession: Actor, Producer, Director, Playwright, Author, Entrepreneur