- Sang and played bass for a Chicago-area rock band called the Apochryphals from 1964 to '69.
- Met his wife, Arlene, in high school; both appeared in a touring company of Hair in 1969, which was Mantegna's professional stage debut.
- In 1978, while with Chicago's Organic Theater Company, cowrote Bleacher Bums, which later played off-Broadway and was adapted for television by the Chicago PBS station (it won a local Emmy).
- Has appeared in six plays and movies written by fellow Chicagoan David Mamet, most notably Glengarry Glen Ross, for which he won a Tony.
- Has set a record for guest appearances on The Simpsons, as Springfield mob chieftain Fat Tony.
- Joined Criminal Minds at the beginning of the show's third season to replace departing star Mandy Patinkin.
- Daughter Gia was Miss Golden Globe 2011.
- 1997, Emmy — Outstanding Supporting Actor in a Miniseries or Special: Nominee
- 1988, Venice Film Festival — Best Actor: Winner
- 2007, Emmy — Outstanding Supporting Actor in a Miniseries or a Movie: Nominee
- 1999, Golden Globe — Best Performance by an Actor in a Supporting Role in a Series, Miniseries or Motion Picture Made for Television: Nominee
- 1984, Tony — Actor (Featured Role--Play): Winner
- 1999, Emmy — Outstanding Supporting Actor in a Miniseries or a Movie: Nominee
- Mia Mantegna — Daughter
- Ronald Mantegna — Brother
- Joseph Anthony Mantegna — Father
- Mary Ann Novelli Mantegna — Mother
- Arlene Vrhel — Wife
- Gia Mantegna — Daughter
- Attended Morton Junior College, Cicero, IL; attended Goodman School of Drama, Chicago, IL
- Birth Name: Joseph Anthony Mantegna Jr.
- Birth Place: Chicago, IL
- Birthday: November 13, 1947, Scorpio
- Profession: Actor
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