- Earned a degree in finance from Georgetown University and worked as a litigation consultant in Florida before switching careers.
- Performed first stand-up routine in 1991, and then spent four years scripting commercials and studying acting.
- First appearance on David Letterman's show garnered Gaffigan acclaim and an offer to develop the sitcom Welcome to New York, which was canceled after three months.
- Has appeared in more than 200 commercials, including campaigns for Saturn, ESPNews, Energizer, Barnes & Noble.com, Kodak and Rolling Rock. His commanding presence in commercials earned him the title "Salesman of the Year" by Business Week in 1999.
- Appeared in two movies chosen for the 2001 Sundance Film Festival: Super Troopers and Thirty Years to Life.
- Featured in a Late Night with Conan O'Brien animated series called Pale Force.
- Made his Broadway debut in 2011 in That Championship Season, opposite Brian Cox, Chris Noth, Jason Patric and Kiefer Sutherland.
- Joe Gaffigan — Brother
- Jack Gaffigan — Son
- Marre Gaffigan — Daughter
- Mitch Gaffigan — Brother
- Jeannie Gaffigan — Wife
- Michael Gaffigan — Son
- Katie Louise Gaffigan — Daughter
- Georgetown University, Washington, DC (MS in Business, 1988)
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- Birth Place: Chesterton, IN
- Birthday: August 27, 1966,
- Profession: Actor, Stand-up comic, Writer, Producer