Bobby trades his soul for the location of Death so Sam and Dean will have a better chance of stopping the Apocalypse. Meanwhile, the brothers confront Pestilence, who unleashes a deadly virus upon them; Dean attends a meeting with Death.
Virgins mysteriously disappear, and Dean and Bobby learn that dragons are responsible for the kidnappings. Dean seeks out a weapon to slay the beasts, but he must prove himself worthy before he can claim it. Meanwhile, Death tries to restore Sam's soul.
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