- Launched her acting career at the age of 12, doing voice-over work for animator Co Hoedeman's program Masquerade for the National Film Board of Canada.
- Did voice-overs for Canadian cartoons while attending college.
- After graduating from McGill University, attended the Harvard-sponsored Institute of Advanced Theater Training at the American Repertory Theater for two years, appearing in productions of The Tempest and Tartuffe.
- Made guest appearances in two 1999 episodes of David E. Kelley's legal drama The Practice; Kelley then cast her in his short-lived ABC dramedy Snoops, before writing the role of Lauren Davis on Boston Public specifically for her.
- Originally trained in painting, she worked on the art pieces for Patricia Clarkson's character in the indie drama The Station Agent (2003).
- Speaks fluent French.
- 2009, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Comedy Series: Winner
- Clare Gilsig — Mother
- Bobby Salomon — Husband (separated)
- Penelope Clare Salomon — Daughter
- Deborah Gilsig — Sister
- Toby Gilsig — Father
- McGill University, Montreal, Quebec, Canada (BA in English, 1993)
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- Birth Name: Jessalyn Sarah Gilsig
- Birth Place: Montreal, Quebec, Canada
- Profession: Actor
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