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House resumes his post after getting his license back and sets out to form a "dream team." He also treats a porn star (Troy Garity) suffering from eye pain. Meanwhile, Cuddy learns again that the hospital is no place to form healthy relationships.
A brilliant but depressed and substance-abusing physicist who chucked his career because he thinks intelligence is a burden arrives with a number of strange symptoms. Meanwhile, relationships are strained all around at Princeton-Plainsboro.