- Raised by her mother, who was frequently on welfare.
- Nominated for a SAG award at age 12 for her role in Bastard Out of Carolina.
- Won legal emancipation from her mother when she was 15 due to her mother's mismanagement of her career and her earnings.
- Made her leading-role debut in Saved! in 2004, alongside Mandy Moore.
- Made her Broadway debut in 2006 in Doubt opposite Eileen Atkins and Ron Eldard.
- Sings in a band, Jena Malone and Her Bloodstains, and as part of a duo dubbed the Shoe.
- 2015, Independent Spirit Awards — Robert Altman Award: Winner
- 1998, Golden Globe — Best Performance by an Actress in a Miniseries or Motion Picture Made for Television: Nominee
- 1996, Screen Actors Guild Awards — Outstanding Performance by a Female Actor in a Television Movie or Miniseries: Nominee
- 1997, Independent Spirit Awards — Best Debut Performance: Nominee
- 2007, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- Ode Mountain DeLorenzo Malone — Son
- Debbie Malone — Mother
- Madison Mae Malone — Half Sister
- Ethan DeLorenzo — Fiancé
- Birth Place: Sparks, Nevada, United States
- Profession: Actor
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