Dr. Michaela "Mike" Quinn, daughter of a doctor, leaves her stable life in Boston -- answering an ad for a town doctor in Colorado Springs.
Jaded and detached, Johnny Skidmarks (Peter Gallagher) is a crime scene photographer who has no qualms about moonlighting as a blackmailer to earn extra cash.
A soda company gives Phoebe $7,000 after she finds a dismembered thumb in a can of soda. Chandler is smoking again, to his friends' dismay.
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A famous civil war photographer realizes he may be taking his last picture after Dr. Mike discovers that he is going blind.
Dr. Mike discovers Hank's dark secret -- an illegitimate son.
Dr. Mike faces the most difficult challenge of her career when she is forced to operate on Brian after he suffers a brain injury.
Influenced by the pulp romance novels she loves, Colleen develops her first crush -- on Sully -- and schemes a way for him to rescue her from danger.
Sam leaps into his great-grandfather, whose actions have made him the target of Confederate soldiers. Sam fights to keep his family tree intact and finds himself helping the relatives of an important historical figure.
Matthew and Michaela are at odds over his future when he sets out to prove to others -- and to himself -- that he's a grown man ready to take on life -- and decides to marry Ingrid.
As Dr. Mike's birthday approaches, the kids decide to do something about her unmarried status
When Cheyenne medicine man Cloud Dancing is wounded by General Custer, who intends to hang him, Sully and Dr. Mike join forces to help him escape.
"Progress" comes to Colorado Springs, and Sully pays the price.
A wandering cowboy abandons his baby boy and leaves him in Dr. Mike's care.
When Doc Eli, a medicine-show man, arrives in town professing to have created the perfect bottled elixir, Mike sets out to call his bluff, especially when her children's health becomes jeopardized.