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April's sister visits and begins to annoy her. Elsewhere, Callie and Arizona put effort into a reconciliation; Matthew and Jackson join forces after they see a devastating accident; and Cristina is urged to live stream video of an operation.
April's wedding day arrives. Meanwhile, Meredith and Cristina continue to clash; Bailey tells Ben how she honestly feels about his return; Shane inserts himself into a perilous situation; and Derek receives a life-changing phone call.
A nonfraternization policy is issued to hospital staff in the wake of a complaint, leading the couples to worry about their relationships. Meanwhile, Emma and Owen discuss the future; and Richard asks the residents to research an atypical cancer case.