House and his team race to diagnose a 12-year-old's illness - an illness with a shocking origin - and House asks Cameron to come back to her job.
After winning the Republican nomination for presidency, Arnold Vinick (recurring guest star Alan Alda) begins working on his campaign. Bruno Gianelli (recurring guest star Ron Silver - "Ali"), a political strategist, gives the Republican candidate advice about choosing a vice president and handling Vinick's latest controversy--his failure to attend church. Meanwhile, the Democrats are stuck in a three-way race for enough delegates to win the Democratic nomination; Russell (recurring guest star Gary Cole) barely leads Santos (recurring guest star Jimmy Smits); and Hoynes (recurring guest star Tim Matheson--not appearing in this episode) is now a distant third. Bartlet tries to show unity in the party by wrangling the candidates.
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