An old trouble traps the heroes, leaving them vulnerable to a dangerous killer.
Sam and Dean call on fellow hunter Bobby (Jim Beaver) for help with violent occurrences on a college campus, but Bobby has suspicions about both the culprit and the brothers' escalating feud.
Nathan and Dwight race to rescue Audrey from Croatoan, but the consequences of Duke's dark destiny wreak havoc on their plans. Meanwhile, Vince contemplates an unusual sacrifice.
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