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Ben regrets a conversation he had with Derek, fearing it may lead to problems for Bailey. Elsewhere, Cristina finds a friend in Shane; April's wedding plans cause awkwardness for others; and Meredith decides to host Thanksgiving dinner.
April's sister visits and begins to annoy her. Elsewhere, Callie and Arizona put effort into a reconciliation; Matthew and Jackson join forces after they see a devastating accident; and Cristina is urged to live stream video of an operation.
April's wedding day arrives. Meanwhile, Meredith and Cristina continue to clash; Bailey tells Ben how she honestly feels about his return; Shane inserts himself into a perilous situation; and Derek receives a life-changing phone call.