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The sixth season begins with Sam being released from hell and trying to convince Dean to rejoin him in fighting evil. To help persuade him, Sam introduces Dean to a new family led by their grandfather Samuel (Mitch Pileggi).
Sam investigates when babies are kidnapped and their parents are murdered. When he finds a baby who is left behind, he contacts Dean to help with the case. Soon, the brothers encounter a shape-shifter who wants to take the child.
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