A former teen model who exudes beauty and brains (see Not Another Teen Movie), Leigh appeared on a number of short-lived series— That '80s Show, Girls Club, Safe Harbor — before hitting it big in 2007, when she joined the cast of Grey's Anatomy in the role of series star Meredith's half-sister Lexie. Although her Grey's Anatomy character has had her ups-and-downs in love, off screen Leigh is a mother of three who has been married to actor Nathan West since 2002.
- Started working as a model at age 12.
- Did not graduate from high school, but achieved the equivalent by taking the California High School Proficiency Exam.
- Garnered notice playing the "Pretty Ugly Girl" in 2001's Not Another Teen Movie and appeared in the music video for Marilyn Manson's cover of "Tainted Love" which was on the film's sound track.
- She and her brother, Christopher, were originally cast as love interests in Safe Harbor. Their characters were rewritten to accommodate the siblings.
- Met Nathan West when they both auditioned for a TV pilot called Saving Grace in 1999; the show was not picked up, but Leigh and West were married in 2002.
- 2007, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- Taelyn West — Daughter
- Anniston Kae West — Daughter
- Christopher Khayman Lee — Brother
- Nathan West — Husband
- Bob Potts — Father
- Noah Wilde West — Son
- Yvonne Norton — Mother
- Taelyn Leigh West — Daughter