- Served in the U.S. Army 1942-46. On the way to Iwo Jima from Hawaii, he was assigned to Maurice Evans' Special Entertainment Unit and toured the Pacific as a comedian in GI revues.
- Allen Ludden of Password fame was once his captain.
- Originally created the role of comedy writer Rob Petrie for himself in Head of the Family. Ultimately he was replaced by Dick Van Dyke and the series was retitled The Dick Van Dyke Show.
- Won an Emmy in 1995 for playing Alan Brady on Mad About You but was never nominated for the role on The Dick Van Dyke Show.
- Received the Kennedy Center Mark Twain Prize for American Humor in 1999.
- In 2003, wrote a children's book, Tell Me a Scary Story... But Not Too Scary!
- Lent his voice to the role of Santa Claus in the 2009 Christmas special Merry Madagascar.
- Played Betty White's blind date in a 2010 episode of Hot in Cleveland.
- 1963, Emmy — Outstanding Writing Achievement in Comedy: Winner
- 1966, Emmy — Outstanding Comedy Series: Winner
- 1967, Emmy — Outstanding Writing Achievement in Variety: Winner
- 1962, Emmy — Outstanding Writing Achievement in Comedy: Winner
- 1964, Emmy — Outstanding Writing Achievement in Comedy or Variety: Winner
- 1965, Emmy — Outstanding Individual Achievements in Entertainment: Nominee
- 1965, Emmy — Outstanding Program Achievements in Entertainment: Winner
- 1958, Emmy — Best Continuing Supporting Performance by an Actor in a Dramatic or Comedy Series: Winner
- 2004, Emmy — Outstanding Special Class Program: Nominee
- 1995, Emmy — Outstanding Guest Actor in a Comedy Series: Winner
- 1966, Emmy — Special Classifications of Individual Achievements: Nominee
- 1998, Grammy — Best Spoken Comedy Album: Winner
- 1954, Emmy — Best Series Supporting Actor: Nominee
- 1957, Emmy — Best Supporting Performance by an Actor: Winner
- 1956, Emmy — Best Actor in a Supporting Role: Nominee
- 2000, Emmy — Outstanding Guest Actor in a Comedy Series: Nominee
- Irving Reiner — Father
- Lucas Reiner — Son
- Rob Reiner — Son
- Bessie Reiner — Mother
- Charles Reiner — Brother
- Sylvia Anne Reiner — Daughter
- Estelle Reiner — Wife (deceased)
- Attended Georgetown University, Washington, DC
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