- Made stage debut at age 12 as an understudy in Harvey Fierstein's 1984 Off-Broadway play Spook House; also appeared on stage in revivals of Paddy Chayefsky's The Tenth Man (1989) and Tennessee Williams' The Rose Tatttoo (1995).
- Was nominated for a Daytime Emmy for Abby, My Love, a 1991 CBS Schoolbreak Special about a teen who's sexually abused by her father. (Buono later counseled rape victims at New York City's Roosevelt Hospital.)
- Wrote and directed the 1997 short film Baggage (starring Minnie Driver and Liev Schreiber).
- Film credits range from The Hulk and Artie Lange's Beer League to the 1999 indie romance Two Ninas (which she co-produced).
- Has run in three New York City Marathons.
- Is certified to teach yoga.
- 2010, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- 2011, Emmy — Outstanding Guest Actress in a Drama Series: Nominee
- Peter Thum — Husband
- Columbia University, New York, NY (BA in English and Political Science, 1993)
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- Birth Place: Bronx, NY
- Birthday: March 1, 1971, Pisces
- Profession: Actor, Screenwriter, Director
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Grey's Anatomy is obviously a big influence on Tay Tay