- Daughter of famous publicist Lois Smith.
- Played bass in a band during high school.
- Studied at the Actors' Studio.
- Made her film debut in 1988's The Moderns.
- Gained 25 pounds for her role as the kidnapped Catherine Martin in The Silence of the Lambs; had nightmares about the role beforehand, but found all the screaming she did during filming to be therapeutic.
- Is also a successful journalist who has interviewed celebrities such as Ed Harris and Steve Buscemi.
- Role as Dr. Erica Hahn on Grey's Anatomy reunited her with some of her previous costars: Ellen Pompeo (a 1996 episode of Law & Order), Sandra Oh (they played lovers in Stop Kiss, a 1998 play) and Patrick Dempsey (2004's Iron Jawed Angels).
- 1995, Independent Spirit Awards — Best Supporting Female: Nominee
- 2007, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- Luke Smith — Brother
- Scott Smith — Brother
- Steven Lubensky — Husband
- Lucy Dinknesh Lubensky — Daughter
- Lois Smith — Mother
- Gene Smith — Father
- Fanny Lubensky — Daughter
- Eric Smith — Brother
- Attended the American Academy of Dramatic Arts, New York, New York, United States
- Birth Place: New York, New York, United States
- Profession: Actor, Journalist
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